The Met Office has issued a rare amber-level weather warning for snow, meaning there is a "potential risk to life".
A number of less serious yellow-level warnings have been in place this week with widespread snow blasting the UK.
However, the Met Office now reckon that some regions could see 40cm (16 inches) of snow across Thursday (March 9) and Friday (March 10), meaning the warning level has increased.
READ MORE: UK weather maps show where Arctic snow will fall as '12 inches to hit Brits'
The area under the new warning stretches from Derby as far as Durham, with Sheffield, Leeds, parts of Greater Manchester and Bradford all impacted.
The warning is in place from 3pm on Thursday to midday on Friday.
The Met Office said: "Snow is expected to develop over northern England on Thursday morning, becoming persistent through the afternoon and overnight into early Friday morning before slowly easing.
"Residual impacts from snowfall are expected to persist through Friday morning. 10-20 cm of snow is expected to fall quite widely, with some places seeing 30-40 cm.
"Strong easterly winds are expected to accompany this snow, leading to blizzards and drifting of lying snow."
Regarding what people under an amber warning can expect, the Met Office website says: "There is an increased likelihood of impacts from severe weather, which could potentially disrupt your plans.
"This means there is the possibility of travel delays, road and rail closures, power cuts and the potential risk to life and property. You should think about changing your plans and taking action to protect yourself and your property.
"You may want to consider the impact of the weather on your family and your community and whether there is anything you need to do ahead of the severe weather to minimise the impact."
As part of this warning specifically, people have been told there is a "good chance" some rural communities could become cut off.
Travel cancellations and power cuts have been deemed "likely", and the warning added there "may be" interruptions to mobile phone service.
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